LRRK2 A419V variant is a risk factor for Parkinson's disease in Asian population

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• 作者：Kai Li^a ; Bei-sha Tang^a ; ^b ; ^c ; ^d ; Zhen-hua Liu^a ; Ji-feng Kang^a ; Yuan Zhang^a ; Lu Shen^a ; ^b ; ^c ; ^d ; Nan Li^a ; ^c ; ^d ; Xin-xiang Yan^a ; ^c ; ^d ; Kun Xia^b ; Ji-feng Guo^a ; ^b ; ^c ; ^d ; ^{guojifeng2003@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：LRRK2 ; A419V ; rs34594498 ; Parkinson's disease ; Cognitive impairment
• 刊名：Neurobiology of Aging
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：36
• 期：10
• 页码：2908.e11-2908.e15
• 全文大小：538 K

文摘

Recently, LRRK2 A419V (rs34594498) was reported associating with Parkinson's disease (PD) in Asian population; yet the conclusion is still unobvious. We conducted a case-control study to determine the potential associations between A419V and PD in Chinese population. Five hundred PD patients and 574 health controls were genotyped. Our results showed, A419V has a significantly higher frequency among PD patients than the controls (p = 0.025, odds ratio [OR] = 2.57, 95% confidence interval [CI] [1.13–5.86]), especially in early-onset PD (p = 0.027, OR = 10.40, 95% CI [1.31–82.89]). And PD patients who carried A419V have a lower Minimum-Mental State Examination scores than PD patients who did not (p = 0.04). We also conducted a meta-analysis on A419V. In Asian population, A419V was detected at a significantly higher frequency among PD patients in contrast to controls: Z = 2.47, p = 0.01, OR = 2.11, 95% CI [1.17–3.82]. When only considering the Chinese population, the difference was more obvious with Z = 3.41, p = 0.0007, OR = 2.07, 95% CI [1.36–3.14]. The results suggest LRRK2 A419V appears to be a risk factor for PD in Asian, especially in early-onset patients. Finally, larger sample with centering on young or cognitive impairment PD patients in Asian would be preferable for further confirmation.