A metabolomics strategy to explore urinary biomarkers and metabolic pathways for assessment of interaction between Danhong injection and low-dose aspirin during their synergistic treatment
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- 作者：Jianping Lia ; b ; Jianming Guoa ; b ; njuguo@njucm.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Erxin Shanga ; b ; Zhenhua Zhua ; b ; Kevin Yue Zhua ; b ; Shujiao Lia ; b ; Buchang Zhaoc ; Lifu Jiac ; Jing Zhaoc ; Zhishu Tangd ; Jinao Duana ; b ; dja@njucm.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Interaction ; Metabolomics ; Drug combination ; Danhong injection ; Aspirin
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：168-175
- 全文大小：2984 K
文摘
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Metabolomics was potent for the assessment of drug interaction.
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Interaction between DHI and low-dose ASA would attach new influence on internal environment.
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Eleven biomarkers were identified and seven metabolic pathways were constructed.
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The biomarkers and metabolic pathways were associated with a lot of reported drugs and diseases.