Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives

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• 作者：Jinbing Liu ; Rihui Cao ; Qifeng Wu ; Chunming Ma ; Zihou Wang ; Wenlie Peng ; Huacan Song
• 关键词：Houttuynin ; β ; -Ketone aldehyde ; Synthesis ; Antibacterial activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2009
• 出版时间：April 2009
• 年：2009
• 卷：44
• 期：4
• 页码：1737-1744
• 全文大小：275 K

文摘

A series of novel 4-alkylphenyl β-aldehyde ketones and their derivatives were designed and synthesized on the basis of the chemical structures of Houttuynin and β-lactam antibiotics. Antibacterial activities of these compounds were investigated. The results demonstrated that most of the compounds tested had moderate antibacterial activities against Gram-positive pathogen Staphylococcus aureus (ATTC-25923) than Houttuynin, and Gram-positive bacteria were more susceptible to the compounds than Gram-negative bacteria. Compound 23 was found to be the most potent compound with MIC of 1.0 μg/mL against S. aureus. Particularly, compounds 16, 22 and 23 showed more active antibacterial activities against the clinically important pathogenic bacteria, methicillin-resistant S. aureus (MRSA) than Houttuynin and levofloxacin. The preliminary structure–activity relationship (SAR) analysis suggested that (1) the introduction of appropriate alkyl substituents into position 4 of phenyl ring enhanced antibacterial activities of these compounds, and isopropyl substituent might be more favorable; (2) the presence of ketone carbonyl moiety might play a vital role in determining significant antibacterial activities of these compounds.