Resveratrol-loaded folic acid-grafted dextran stearate submicron particles exhibits enhanced antitumor efficacy in non-small cell lung cancers

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• 作者：Qing-sheng Zhao^a ; ¹ ; Ling-ling Hu^b ; ¹ ; Zhi-dong Wang^a ; Zhao-pei Li^c ; Ai-wen Wang^d ; Jing Liu^e ; ^{jingliu1979@hotmail.com}
• 关键词：Lung cancers ; Polymeric micelles ; Resveratrol ; Anticancer efficacy
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：185-191
• 全文大小：845 K
• 卷排序：72

文摘

Folic acid-conjugated dextran stearate (DF) submicron particles to enhance RSV efficacy in lung cancers RSV-DF micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions. RSV-DF showed an enhanced cellular apoptosis of cancer cells compared to that of free RSV. RSV could be an interesting prospect to treat lung cancers.