Solubility measurement, model evaluation and thermodynamic analysis of rivaroxaban polymorphs in organic solvents
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- 作者：Jinghuan Zhai ; Zhenzhen Chen ; Xijian Liu ; Lijuan Zhang ; Jie Lu ; lujie@sues.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Solubility ; Polymorph ; Rivaroxaban ; Measurement ; Thermodynamic modelling
- 刊名：Journal of Chemical Thermodynamics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：104
- 期：Complete
- 页码：218-229
- 全文大小：1151 K
文摘
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The solubility of form II of rivaroxaban in organic solvents was firstly reported.
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Wilson, NRTL and UNIQUAC were evaluated to model the solubility.
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The apparent standard enthalpy change of the dissolution of both forms was analyzed.