Nanoscale metal−organic frameworks for combined photodynamic & radiation therapy in cancer treatment

详细信息    查看全文

• 作者：Jingjing Liu^a ; Yu Yang^b ; Wenwen Zhu^a ; Xuan Yi^c ; Ziliang Dong^a ; Xiaona Xu^a ; Meiwan Chen^b ; Kai Yang^c ; Guang Lu^a ; Lixin Jiang^d ; ^{jinger_28@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Zhuang Liu^a ; ^{zliu@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nanoscale metal&minus ; organic framework ; Photodynamic therapy ; Radiation therapy ; Combination therapy
• 刊名：Biomaterials
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：97
• 期：Complete
• 页码：1-9
• 全文大小：2275 K

文摘

Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf⁴⁺) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf⁴⁺ with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions.