Recombinant NDV expressing cytokines or fliC confers a quick immune response against NDV challenge and resistance to maternal antibody

详细信息    查看全文

• 作者：Tianyuan Zhang^a ; ¹ ; Yunye Liu^a ; ¹ ; Hui Wang^a ; Xu Zhang^a ; Shenglong Zhu^b ; Pengfei Xu^a ; Jiechao Yin^a ; Guiping Ren^a ; ^{renguiping@126.com} ; Jingli Liu^c ; ^{13796007273@163.com} ; Deshan Li^a ; ^{deshanli@163.com}
• 关键词：Recombinant newcastle disease virus ; Reverse genetics ; Cytokines ; Bio-adjuvant ; Vaccines ; Maternal antibodies
• 刊名：Veterinary Microbiology
• 出版年：2016
• 出版时间：30 November 2016
• 年：2016
• 卷：196
• 期：Complete
• 页码：107-117
• 全文大小：2725 K
• 卷排序：196

文摘

We generated four recombinant NDVs expressing chIL2, chIL15, chGM-CSF and fliC gene. The rNDVs could induce quicker immune response than parental viruses. The rNDVs expressing chGM-CSF and fliC could resist the interference of maternal antibodies.