Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression
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- 作者：Shenglong Cao ; Ping Zhu ; Xiaobo Yu ; Jingyin Chen ; Jianru Li ; Feng Yan ; Lin Wang ; Jun Yu ; Gao Chen ; d-chengao@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrogen sulfide ; Subarachnoid hemorrhage ; Brain edema ; Blood-brain barrier ; AQP4
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：16 May 2016
- 年：2016
- 卷：621
- 期：Complete
- 页码：88-97
- 全文大小：3364 K
文摘
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We explored the effect of H2S on early brain edema formation in a rat model of subarachnoid hemorrhage.
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H2S significantly alleviated brain edema, consequently reduced cell death and improved neurological deficits.
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H2S inhibited early brain edema formation partially by reducing BBB disruption and down-regulating AQP4 expression.
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H2S stabilized BBB by inhibiting MMP-9 induced tight junction degradation between endothelial cells.