Overexpression of HMGB1 A-box reduced IL-1β-induced MMP expression and the production of inflammatory mediators in human chondrocytes
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- 作者：Yahui Fu ; Jinlai Lei ; leijinlai@126.com" class="auth_mail" title="E-mail the corresponding author ; Yan Zhuang ; Kun Zhang ; Daigang Lu
- 关键词：High mobility group box 1 A-box (HMGB1 A-box) ; Matrix metalloproteinase (MMP) ; Toll-like receptor 4 (TRL4) ; Nuclear factor-kappa B (NF-κB) ; Osteoarthritis (OA)
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：184-190
- 全文大小：928 K
文摘
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Overexpression of HMGB1 A-box downregulated MMP expression in IL-1β-stimulated chondrocytes.
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Overexpression of HMGB1 A-box inhibited IL-1β-induced iNOS and COX-2 expression.
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Overexpression of HMGB1 A-box suppressed the expression of ADAMTS-4 and ADAMTS-5 in IL-1β-induced chondrocytes.
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Effects of overexpression of HMGB1 A-box on HMGB1/TLR4/NF-κB signaling.