Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity
详细信息 查看全文
- 作者：Han Wei ; Xuenong Zhang ; Guanghua Wu ; Xian Yang ; Songwei Pan ; Yanyan Wang ; Jinlan Ruan
- 关键词：Cyclosorus parasiticus ; Chalcone ; Anti-proliferative activity ; HepG2 cell
- 刊名：Food and Chemical Toxicology
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：60
- 期：Complete
- 页码：147-152
- 全文大小：1355 K
文摘
Three new chalcone derivatives, named parasiticins A-C (1-3), were isolated from the leaves of Cyclosorus parasiticus, together with four known chalcones, 5,7-dihydroxy-4-phenyl-8-(3-phenyl-trans-acryloyl)-3,4-dihydro-1-benzopyran-2-one (4), 2¡ä-hydroxy-4¡ä,6¡ä-dimethoxychalcone (5), 2¡ä,4¡ä-dihydroxy-6¡ä-methoxy-3¡ä,5¡ä-dimethylchalcone (6), 2¡ä,4¡ä-dihydroxy-6¡ä-methoxy-3¡ä-methylchalcone (7). The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of compounds 1-7 were evaluated against six human cancer cell lines in vitro. Compounds 3 and 6 exhibited substantial cytotoxicity against all six cell lines, especially toward HepG2 with the IC50 values of 1.60 and 2.82 ¦ÌM, respectively. Furthermore, we demonstrated that compounds 3 and 6 could induce apoptosis in the HepG2 cell line, which may contribute significantly to their cytotoxicity.