The TNF-α −238G/A and TNF-α −308G/A polymorphisms were determined by TaqMan SNP Genotyping assays in cases (n = 748) and controls (n = 748). Multivariate logistic regression analysis was used to show the association between the TNF-α genotypes and the IS events.
No significant difference was found in the association between TNF-α −238G/A and IS in both ethnic populations. The result showed that carriage of the TNF-α −308GA was a decreased risk of IS in both Han and Uyghur populations (OR:0.453, 0.213). In addition, the significant difference in GA frequency in TNF-α was found between the two ethnic controls (P = 0.000).
TNF-α −308 GA heterozygous may be an independent protective factor for IS in the Chinese Han and Uyghur populations.