Preparation of novel β-cyclodextrin chiral stationary phase based on click chemistry

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• 作者：Yongping Zhang ; Zhimou Guo ; Jinxing Ye ; Qing Xu ; Xinmiao Liang ; Aiwen Lei
• 关键词：β ; -Cyclodextrin ; Chiral stationary phases ; Click chemistry ; Chiral separation
• 刊名：Journal of Chromatography A
• 出版年：2008
• 出版时间：16 May 2008
• 年：2008
• 卷：1191
• 期：1-2
• 页码：188-192
• 全文大小：384 K

文摘

A facile strategy based on click chemistry for preparation of the structurally well-defined native β-cyclodextrin (β-CD) based chiral stationary phase (CSP) was proposed. The β-CD CSP was evaluated by enatioseparation of benzoin, trans-stilbene oxide, Troger's base, bendroflumethiazide, ketoprofen, chlorthalidone, three flavanone compounds and two β-adrenergic blocking agents under reversed phase high performance liquid chromatography. The chromatographic results demonstrate the chiral separation ability of click β-CD CSP and illustrate the usefulness of click chemistry in the preparation of β-CD based CSP.