FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1

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• 作者：Zhe Zhang^a ; Limeng Liu^a ; Kwame Twumasi-Boateng^a ; ^b ; ¹ ; Dena H.S. Block^a ; Michael Shapira^a ; ^b ; ^{mshapira@berkeley.edu}
• 关键词：SAPK ; stress-activated protein kinase ; MAPK ; mitogen-activated protein kinase ; JNK ; c-Jun N-terminal kinases ; AP-1 ; activator protein-1 ; ANOVA ; Analysis of Variance
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：1-8
• 全文大小：895 K
• 卷排序：30

文摘

KGB-1 activation in different ages causes a robust gene induction. FOS-1 is an essential activator for KGB-1-dependent age-invariant gene expression. FOS-1 mediates a regulatory feedback loop in KGB-1 signaling. FOS-1 acts in parallel to DAF-16 in mediating KGB-1-dependent gene expression. DAF-16 mediates age-dependent contributions of KGB-1 to stress resistance.