Zinc-dependent binding between peptides derived from rainbow trout CD8α and LCK
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- 作者：Nobuhiro Hayashi ; Masami Takeuchi ; Teruyuki Nakanishi ; Keiichiro Hashimoto ; Johannes Martinus Dijkstra
- 关键词：Rainbow trout ; CD8α ; CD8β ; LCK ; Cytoplasmic tail ; Zinc clasp ; Surface plasmon resonance binding assay
- 刊名：Fish & Shellfish Immunology
- 出版年：2010
- 出版时间：January 2010
- 年：2010
- 卷：28
- 期：1
- 页码：72-76
- 全文大小：1109 K
文摘
The cytoplasmic tail of mammalian CD8α binds the kinase LCK in a zinc-dependent manner. In analogy with a previous study for humans (Kim et al., 2003) peptides were synthesized from rainbow trout CD8α and LCK. Surface plasmon resonance (SPR) analysis indicated that also in fish these molecules bind to each other in a zinc-dependent manner.