Iron-sulfur cluster damage by the superoxide radical in neural tissues of the SOD1G93A ALS rat model
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- 作者：Ana Popović-Bijelića ; ana@ffh.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author ; Milo&scaron ; Mojovića ; Stefan Stamenkovićb ; Milo&scaron ; Jovanovićb ; Vesna Selakovićc ; Pavle Andjusb ; Goran Bačića
- 关键词：ALS ; amyotrophic lateral sclerosis ; cyt c ; cytochrome c ; CcO ; cytochrome c oxidase ; EPR ; electron paramagnetic resonance ; NTg ; nontransgenic ; Tg ; transgenic ; RNS ; reactive nitrogen species ; ROS ; reactive oxygen species
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：313-322
- 全文大小：928 K
文摘
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SOD1G93A ALS rat model spinal cords and brainstems contain more Mn than NTg.
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Increased [3Fe-4S]1+ relative to [4Fe-4S]1+ in SOD1G93A compared to NTg.
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KO2 addition to rat brains leads to [4Fe-4S]→[3Fe-4S] conversion and iron release.
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Superoxide causes oxidative damage to SOD1G93A rat neural tissues.
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Iron-sulfur clusters may be the source of poorly liganded redox active iron.