Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance

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• 作者：Julia Hess^a ; ^c ; ^{julia.hess@helmholtz-muenchen.de} ; Kristian Unger^a ; ^c ; ^{unger@helmholtz-muenchen.de} ; Michael Orth^b ; ^{michael.orth@med.uni-muenchen.de} ; Ulrike Sch&ouml ; tz^b ; ^{ulrike.schoetz@med.uni-muenchen.de} ; Lars Schü ; ttrumpf^b ; ^c ; ^{lars.schuettrumpf@med.uni-muenchen.de} ; Verena Zangen^a ; ^c ; ^{verena.zangen@helmholtz-muenchen.de} ; Igor Gimenez-Aznar^a ; ^{igor.gimenez-aznar@helmholtz-muenchen.de} ; Agata Michna^a ; ^{agata.michna@helmholtz-muenchen.de} ; Ludmila Schneider^a ; ^c ; ^{ludmila.schneider@helmholtz-muenchen.de} ; Ramona Stamp^b ; ^c ; ^{ramona.stamp@googlemail.com} ; Martin Selmansberger^a ; ^{martin.selmansberger@helmholtz-muenchen.de} ; Herbert Braselmann^a ; ^c ; ^{braselm@helmholtz-muenchen.de} ; Ludwig Hieber^a ; ^c ; ^{ludwig.hieber@arcor.de} ; Guido A. Drexler^b ; ^{guido.drexler@lrz.uni-muenchen.de} ; Sebastian Kuger^a ; ^c ; ^{sebastian.kuger@helmholtz-muenchen.de} ; Diana Klein^d ; ^{Diana.Klein@uk-essen.de} ; Verena Jendrossek^d ; ^{verena.jendrossek@uni-due.de} ; Anna A. Friedl^b ; ^c ; ^{anna.Friedl@med.uni-muenchen.de} ; Claus Belka^b ; ^c ; ^{claus.belka@med.uni-muenchen.de} ; Horst Zitzelsberger^a ; ^c ; ^{zitzelsberger@helmholtz-muenchen.de} ; Kirsten Lauber^b ; ^c ; ^{kirsten.lauber@med.uni-muenchen.de}
• 关键词：Head and neck squamous cell carcinoma ; Fanconi anemia ; Radiotherapy ; Radioresistance ; Senescence ; DNA damage repair
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：87-99
• 全文大小：4160 K
• 卷排序：386

文摘

Gains on 16q24.3 associate with FancA overexpression and impaired overall survival. FancA overexpression confers radioresistance with improved DNA repair in vitro. No hyperactivation of the FA/BRCA-pathway is observed. Interferon signaling is attenuated, senescence, and SASP production are enforced. FancA-associated transcriptomic alterations are reflected in clinical HNSCC samples.