Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity
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- 作者：Bruno M. Simõ ; es1 ; 9 ; Ciara S. O&rsquo ; Brien1 ; 9 ; Rachel Eyre1 ; Andreia Silva1 ; Ling Yu1 ; Aida Sarmiento-Castro1 ; Denis G. Alfé ; rez1 ; Kath Spence1 ; Angé ; lica Santiago-Gó ; mez1 ; Francesca Chemi1 ; 2 ; Ahmet Acar3 ; Ashu Gandhi4 ; Anthony Howell1 ; Keith Brennan3 ; Lisa Rydé ; n5 ; Stefania Catalano2 ; Sebastiano Andó ; 2 ; Julia Gee6 ; Ahmet Ucar1 ; 3 ; Andrew H. Sims7 ; Elisabetta Marangoni8 ; Gillian Farnie1 ; Gö ; ran Landberg1 ; Sacha J. Howell1 ; sacha.howell@christie.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Robert B. Clarke1 ; robert.clarke@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 September 2015
- 年：2015
- 卷：12
- 期：12
- 页码：1968-1977
- 全文大小：3121 K
文摘
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Anti-estrogen therapies selectively enrich for BCSCs and activate Notch signaling
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Notch pathway activation and ALDH1 predict for anti-estrogen treatment failure
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Targeting of Notch4 reduces the population of BCSCs
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Notch inhibitors might prevent relapse or overcome resistance in ER+ tumors