Proteolytic Cleavage Governs Interleukin-11 Trans-signaling
详细信息 查看全文
- 作者：Juliane Lokau1 ; Rebecca Nitz2 ; Maria Agthe1 ; Niloufar Monhasery2 ; Samadhi Aparicio-Siegmund1 ; Neele Schumacher1 ; Janina Wolf1 ; Katja Mö ; ller-Hackbarth1 ; Georg H. Waetzig4 ; Joachim Grö ; tzinger1 ; Gerhard Mü ; ller-Newen3 ; Stefan Rose-John1 ; Jü ; rgen Scheller2 ; jscheller@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author ; Christoph Garbers1 ; cgarbers@biochem.uni-kiel.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：interleukin-11 ; ADAM10 ; ADAM17 ; proteolysis ; signal transduction
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 February 2016
- 年：2016
- 卷：14
- 期：7
- 页码：1761-1773
- 全文大小：3963 K
文摘
- •
The IL-11R is a substrate for ADAM10, but not ADAM17
- •
A juxtamembrane region determines the substrate specificity of ADAM17
- •
The soluble IL-11R binds IL-11 and initiates IL-11 trans-signaling
- •
IL-11 trans-signaling can be blocked by the anti-inflammatory therapeutic sgp130Fc