The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats
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- 作者：Daniele Lanaa ; daniele.lana@unifi.it" class="auth_mail" title="E-mail the corresponding author ; Ludovica Iovinob ; 1 ; ludovica.iovino@unifi.it" class="auth_mail" title="E-mail the corresponding author ; Daniele Nosib ; daniele.nosi@unifi.it" class="auth_mail" title="E-mail the corresponding author ; Gary L. Wenkc ; wenk.6@psy.ohio-state.edu" class="auth_mail" title="E-mail the corresponding author ; Maria Grazia Giovanninia ; mariagrazia.giovannini@unifi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：aCSF ; artificial cerebrospinal fluid ; AD ; Alzheimer's disease ; AL ; acquisition latency ; CA ; Cornu Ammonis ; CytC ; cytochrome C ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; ERK ; extracellular regulated kinase ; GABA ; gamma-aminobutyric acid ; GFAP ; glial fibrillary acidic protein ; iNOS ; inducible nitric oxide synthase ; IA ; inhibitory avoidance ; IBA1 ; ionized calcium binding adaptor 1 ; JNK ; c-Jun N-terminal kinase/stress activates protein kinase ; LPS ; lipopolysaccharide ; LTM ; long term memory ; LTP ; long term p
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：71-88
- 全文大小：3158 K
文摘
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In CA3 SL and SR of aged rats astrocytes formed “triads” with microglia and neurons.
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Astrocytes and microglia cooperated in the phagocytosis of apoptotic neurons.
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Inflammaging-induced triads formation help clearing neurons and neuronal debris.
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Triads formation may be a mechanism common to many neurodegenerative processes.