Convenient and efficient decarboxylative aldol reaction of malonic acid half esters with trifluoromethyl ketones

详细信息    查看全文

• 作者：Xiao-Juan Li ; Heng-Ying Xiong ; Ming-Qing Hua ; Jing Nie ; Yan Zheng ; Jun-An Ma ; ^{majun_an68@tju.edu.cn}
• 关键词：Decarboxylative aldol condensation ; Malonic acid half esters ; Trifluoromethyl ketones ; Stereoselectivity ; Reduction
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：18 April, 2012
• 年：2012
• 卷：53
• 期：16
• 页码：2117-2120
• 全文大小：2496 K

文摘

A convenient and efficient decarboxylative ketone aldol condensation of malonic acid half esters was reported. In the presence of catalytic amount of triethylamine, a series of aromatic and alkyl trifluoromethyl ketones were transformed into the desired adducts in 61-99 % yields. In a preliminary experiment, a moderate stereoselectivity was obtained. Direct reduction of the aldol product with LiAlH₄ afforded trifluoromethylated 1,3-diol.