Two novel furan derivatives from Phellinus linteus with anti-complement activity

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• 作者：Byung-Sun Min ; Bong-Sik Yun ; Hyeong-Kyu Lee ; Hee-Jin Jung ; Hyun-Ah Jung and Jae-Sue Choi
• 关键词：Phellinus linteus ; Furan derivatives ; Structural determination ; Anti-complement activity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 June 2006
• 年：2006
• 卷：16
• 期：12
• 页码：3255-3257
• 全文大小：98 K

文摘

Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC₅₀ values of 33.6 and 33.7 μM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.