Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7
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- 作者：Chongyuan Wang1 ; Yuwei Zhu1 ; Tamar B. Caceres2 ; Lei Liu1 ; Junhui Peng1 ; Junchen Wang1 ; Jiajing Chen1 ; Xuwen Chen1 ; Zhiyong Zhang1 ; Xiaobing Zuo3 ; Qingguo Gong1 ; Maikun Teng1 ; Joan M. Hevel2 ; Jihui Wu1 ; wujihui@ustc.edu.cn" class="auth_mail ; Yunyu Shi1 ; yyshi@ustc.edu.cn" class="auth_mail
- 刊名：Structure
- 出版年：6 May 2014
- 年：2014
- 卷：22
- 期：5
- 页码：756-768
- 全文大小：4318 K
文摘
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The structure of TbPRMT7 in complex with AdoHcy and H4 peptide was solved
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TbPRMT7 forms a homodimer with dimer interfaces and a bowl-like structure
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The active site of TbPRMT7 is much narrower than those of dimethyltransferases
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TbPRMT7 is unsuitable to bind MMA in a manner supporting SDMA and ADMA formation