Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3
详细信息 查看全文
- 作者：Duanmin Hua ; 1 ; Cunjin Sub ; 1 ; Min Jiangc ; Yating Shena ; Aiming Shib ; Fenglun Zhaob ; Ruidong Chena ; Zhu Shenb ; Junjie Baob ; baojjsdfey@sina.com" class="auth_mail" title="E-mail the corresponding author ; Wen Tanga ; sztangwen@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Long non-coding RNAs ; Fenofibrate ; Pancreatic cancer ; MEG3 ; p53 ; Microarray analysis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 March 2016
- 年：2016
- 卷：471
- 期：2
- 页码：290-295
- 全文大小：1518 K
文摘
- •
We found that fenofibrate suppressed proliferation of pancreatic cancer cells.
- •
We found fenofibrate increased LncRNA-MEG3 expression and p53 level in PANC-1 cells.
- •
Inhibition of MEG3 expression attenuated anti-tumor effects of fenofibrate.