Numerical simulation and experimental study of resonance characteristics of QCM-P devices operating in liquid and their application in biological detection

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• 作者：Pengtao Wang^aAuthor Vitae ; Junwei Su^a ; Lin Gong^a ; Mengyan Shen^b ; Marina Ruths^c ; Hongwei Sun^a ; ^{hongwei_sun@uml.edu" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：QCM ; Micropillar ; PMMA ; Liquid phase ; Improved mass sensitivity
• 刊名：Sensors & Actuators: B. Chemical
• 出版年：2015
• 出版时间：1 December 2015
• 年：2015
• 卷：220
• 期：Complete
• 页码：1320-1327
• 全文大小：1977 K

文摘

Quartz Crystal Microbalance - micropillar (QCM-P) devices rely on system resonance between the QCM crystal and micropillars directly fabricated on its surface to obtain ultrahigh sensitivity. A numerical model was developed to study the effect of hydrodynamic loadings on a QCM-P device. The effect of substrates with inherent resonant frequencies of 5 and 10 MHz on device performance was also studied numerically. The QCM-P device showed different resonant frequency and amplitude while operated in air or water. As a demonstration of applications of QCM-P in biological detection, a 5 MHz QCM-P device was used to measure acrylic acid grafted on oxygen plasma treated poly(methyl methacrylate) (PMMA) micropillar surfaces. The QCM-P device produced a much higher frequency response than a conventional QCM sensor.