Mitochondrial tRNA mutations in 2070 Chinese Han subjects with hypertension
详细信息 查看全文
- 作者：Ling Xuea ; 1 ; Meng Wangb ; c ; 1 ; Haiying Lia ; d ; Heng Wanga ; Feng Jianga ; Lingling Houa ; Junwei Genga ; Zhi Lina ; Yanyan Pengb ; e ; Hong Zhoub ; Han Yua ; Pingping Jiangb ; c ; Jun Qin Mof ; Min-Xin Guana ; b ; c ; g ; gminxin88@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypertension ; Mitochondrial genetic defect ; tRNA variants ; Translation ; Metabolism ; Pathophysiology
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：208-221
- 全文大小：1368 K
文摘
- •
165 mitochondrial tRNA variants were identified in 2070 Chinese hypertensive subjects.
- •
47 variants were identified as putative hypertension-associated tRNA variants.
- •
These tRNA variants caused the structural and functional alterations.
- •
The tRNA variants are the important causes of hypertension.