Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection
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- 作者：Wenjing Zhanga ; Junyan Taoa ; Xiaoping Yanga ; Zhuliang Yangb ; Li Zhangc ; Hongsheng Liuc ; Kailang Wua ; Jianguo Wua ; jwu@whu.edu.cn" class="auth_mail
- 关键词：Enterovirus 71 (EV71) ; Virus infection ; Hand-foot-mouth disease (HFMD) ; Ganoderma lucidum triterpenoids (GLTs) ; Antiviral activity ; Potential therapeutic antiviral agents
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：4 July 2014
- 年：2014
- 卷：449
- 期：3
- 页码：307-312
- 全文大小：1091 K
文摘
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Triterpenoids GLTA and GLTB display anti-EV71 activities without cytotoxicity.
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The compounds prevent EV71 infection by blocking adsorption of the virus to the cells.
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GLTA and GLTB bind to EV71 capsid at the hydrophobic pocket to block EV71 uncoating.
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The two compounds significantly inhibit the replication of EV71 viral RNA.
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GLTA and GLTB may be used as potential therapeutic agents to treat EV71 infection.
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