An efficient method for the construction of 2-Aminothiazolo[5,4-c]pyridines via K₃[Fe(CN)₆] oxidized SP² CH Functionalization

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• 作者：De-Zhi Wu^a ; ^b ; Yong-Gang Zhi^a ; ^{zyggroup@hotmail.com}
• 关键词：Pyridylthioureas ; Thiazolo[5 ; 4-c]pyridines ; K3[Fe(CN)6] ; Oxidative cyclization ; Free-radical
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：29 December 2016
• 年：2016
• 卷：72
• 期：52
• 页码：8610-8616
• 全文大小：1614 K
• 卷排序：72

文摘

A practical approach to synthesize 2-aminothiazolo[5,4-c]pyridines from simple asymmetric pyridylthioureas was achieved by utilizing K3[Fe(CN)6] as the oxidant. These reactions went through an intramolecular oxidation and finally led to the formation of CS bond. Furthermore, the possible oxidative cyclization mechanism was also explored by the addition of radical scavengers, which showed that the oxidative cyclization was promoted via a free radical mechanism.