Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

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• 作者：Hanna Piotrowska-Kempisty^a ; ^{hanna.piotrowska@ump.edu.pl} ; Agnieszka Klupczyńska^b ; ^{aklupczynska@ump.edu.pl} ; Dorota Trzybulska^c ; ^{trzybulskadorota@gmail.com} ; Katarzyna Kulcenty^d ; ^{katarzyna.kulcenty@wco.pl} ; Anna Maria Sulej-Suchomska^b ; ^{sulejsuchomska@ump.edu.pl} ; Małgorzata Kucińska^a ; ^{kucinska@umed.poznan.pl} ; Renata Mikstacka^e ; ^{rmikstac@ump.edu.pl} ; Marcin Wierzchowski^e ; ^{mwierzch@ump.edu.pl} ; Marek Murias^a ; ^{marek.murias@ump.edu.pl} ; Wanda Baer-Dubowska^f ; ^{baerw@ump.edu.pl} ; Zenon Kokot^b ; ^{zjk@ump.edu.pl} ; Jadwiga Jodynis-Liebert^a ; ^{liebert@ump.edu.pl}
• 关键词：Resveratrol ; DMU-212 ; DMU-214 ; Metabolic activation ; CYP1A1
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：267
• 期：Complete
• 页码：59-66
• 全文大小：1751 K
• 卷排序：267

文摘

CYP1A1 is the major enzyme of CYP1 family involved in the biotransformation of DMU-212. The cytotoxic effects of DMU-212 are related to the expression of CYP1A1 enzyme. The biological activity of DMU-212 is associated with its metabolic activation to DMU-214.