Identification and characterization of a mitochondrial unfolded protein response transcription factor ATFS-1 in Litopenaeus vannamei
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- 作者：Yong-Gui Chena ; c ; Hai-Tao Yueb ; c ; Ze-Zhi Zhangb ; c ; Feng-Hua Yuanb ; c ; Hai-Tao Bib ; c ; Kai Yuanb ; c ; Shao-Ping Wengb ; c ; Jian-Guo Hea ; b ; c ; Yi-Hong Chena ; c ; chenyh6@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Litopenaeus vannamei ; ATFS-1 ; ROS ; Innate immunity ; Mitochondrial unfolded protein response
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：144-152
- 全文大小：1958 K
文摘
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Cloning the activating transcription factor associated with stress-1 in Litopenaeus vannamei (designated as LvATFS-1).
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LvATFS-1 could reduced the level of intracellular reactive oxygen species.
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LvATFS-1 upregulated the expression of the antibacterial peptide genes in S2 cells.
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Knocked-down LvATFS-1 caused a higher cumulative mortality upon V. alginolyticus or WSSV infection in L. vannamei.