• 作者：Hironori Kuga ; M.D.^a ; ^b ; Toshiaki Onitsuka ; M.D. ; Ph.D.^a ; ^{toshiaki@npsych.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoji Hirano ; M.D. ; Ph.D.^a ; Itta Nakamura ; M.D. ; Ph.D.^a ; Naoya Oribe ; M.D. ; Ph.D.^a ; ^b ; Hiroaki Mizuhara ; Ph.D.^c ; Ryota Kanai ; Ph.D.^d ; Shigenobu Kanba ; M.D. ; Ph.D.^a ; Takefumi Ueno ; M.D. ; Ph.D.^a ; ^b ; ^{uenotk@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Acute episode schizophrenia ; Bold ; High gamma oscillation ; Auditory steady state response ; Neural over activation ; Auditory hallucination
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：143-149
• 全文大小：884 K

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We investigated neural responses during click stimulation by BOLD signals.

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We evaluated patients with acute and non-acute schizophrenia, and healthy controls.

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80-Hz auditory stimulation activated the left auditory cortex in acute schizophrenia.

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Our data may reflect left auditory cortex glutamate toxicity in acute schizophrenia.

Recent MRI studies show that schizophrenia is characterized by reduced brain gray matter, which deteriorates in the acute state of the disease. Periodic auditory click trains elicit auditory steady-state responses (ASSRs), and ASSR abnormalities are reported in schizophrenia. We investigated neural responses during click stimulation using BOLD signals, which may reflect glutamate toxicity. Compared with non-acute schizophrenia patients and healthy controls, acute episode schizophrenia patients showed significantly increased ASSR-BOLD to 80-Hz stimuli in the left auditory cortex. Our data demonstrate neuronal over activation in terms of the BOLD pattern in acute state schizophrenia, which might reflect progressive volume reduction in the left superior temporal cortex by glutamate toxicity during the acute phase of schizophrenia.