Biodistribution and radiation dosimetry in humans of [¹¹C]FLB 457, a positron emission tomography ligand for the extrastriatal dopamine D₂ receptor

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• 作者：Yasuyuki Kimura ; Hiroshi Ito ; Takahiro Shiraishi ; Hironobu Fujiwara ; Fumitoshi Kodaka ; Harumasa Takano ; Hitoshi Shimada ; Iwao Kanno ; Tetsuya Suhara
• 关键词：Dosimetry ; Positron emission tomography ; [11C]FLB 457 ; Dopamine D2 receptors
• 刊名：Nuclear Medicine and Biology
• 出版年：January, 2014
• 年：2014
• 卷：41
• 期：1
• 页码：102-105
• 全文大小：406 K

文摘

Purpose

[¹¹C]FLB 457, a radioligand with very high affinity and selectivity for dopamine D_2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of [¹¹C]FLB 457 in healthy human subjects.

Methods

Whole-body images were acquired for 2 h after an injection of [¹¹C]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software.

Results

Organs with the longest residence time were the liver, lungs, and brain. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by [¹¹C]FLB 457 is 5.9 渭Sv/MBq, similar to those of other ¹¹C-labeled tracers.

Conclusions

This effective dose would allow multiple scans in the same individual based on prevailing maximum recommended-dose guidelines in the USA and Europe.