Protein Phosphatase-1 regulates Rift Valley fever virus replication
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- 作者：Alan Baera ; Nazly Shafagatia ; Ashwini Benedicta ; Tatiana Ammosovab ; Andrey Ivanovb ; Ramin M. Hakamia ; Kaori Terasakic ; Shinji Makinoc ; Sergei Nekhaib ; Kylene Kehn-Halla ; kkehnhal@gmu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：L polymerase ; Phosphorylation ; Protein phosphatase 1 ; Antiviral agent ; Rift valley fever virus ; Bunyaviridae
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：79-89
- 全文大小：1090 K
文摘
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Protein Phosphatase-1 (PP1) is a critical host factor regulating RVFV replication.
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PP1α deregulation by siRNA or 1E7-03 (small molecule inhibitor) decreases viral titers in vitro across multiple cell lines.
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1E7-03 inhibits RVFV viral RNA production, potentially through modulation of viral N and/or L proteins.
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PP1 deregulation may prove an attractive host targeted therapeutic model, as it is a highly conserved target.