Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children

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• 作者：Keiko Wada ; MD ; PhD^a ; ^{dr_keiko@gifu-u.ac.jp} ; Kozue Nakamura ; MD ; PhD^a ; Yuya Tamai ; MD^a ; Michiko Tsuji ; MEd^a ; Takako Masue ; MD ; PhD^b ; Kaori Watanabe ; MHEs^c ; Kyoko Ando ; MHEs^c ; Chisato Nagata ; MD ; PhD^a
• 关键词：Melatonins ; Body size ; Lifestyle factors ; Sex steroids ; Child
• 刊名：Annals of Epidemiology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：23
• 期：2
• 页码：60-65
• 全文大小：141 K

文摘

Purpose

We aimed to assess the associations of sex, age, body mass, sex steroid hormones, and lifestyle factors with the levels of melatonin in young children.

Methods

This study followed a cross-sectional design and was conducted two preschools in Japan. Subjects were 235 boys and 203 girls, aged 3-6 years. Information related to demographics, body mass, and lifestyle factors was obtained from parent-administered questionnaires. The levels of 6-sulfatoxymelatonin and dehydroepiandrosterone in first-void morning urine were measured by radioimmunoassay. Urinary estrone, estradiol, testosterone, and 5-androstene-3¦Â, 17¦Á diol levels were measured by liquid chromatography-electrospray ionization tandem mass spectrometry.

Results

The creatinine-corrected 6-sulfatoxymelatonin levels and the estimated value of 6-sulfatoxymelatonin excretion were higher in girls than in boys. After adjustments for age, the creatinine-corrected 6-sulfatoxymelatonin was negatively associated with weight and body mass index among boys and with weight and height among girls. However, the estimated value of 6-sulfatoxymelatonin excretion was not associated with any indices of body mass. No significant relationships of urinary sex?steroids, light exposure at night, sleep time, sedentary lifestyles, or passive smoking with urinary 6-sulfatoxymelatonin were observed.

Conclusions

Our findings suggest that melatonin levels depend on sex and body size among young healthy children. Our results should be confirmed in future researches.