Patterns of Peripheral Retinal and Central Macula Ischemia in Diabetic Retinopathy as Evaluated by Ultra-widefield Fluorescein Angiography

详细信息    查看全文

• 作者：Dawn A. Sim^a ; ^b ; ^{dawnasim@gmail.com" class="auth_mail}Author Vitae ; Pearse A. Keane^a ; ^b ; Ranjan Rajendram^a ; ^b ; Michael Karampelas^a ; Senthil Selvam^b ; Michael B. Powner^b ; Marcus Fruttiger^b ; Adnan Tufail^a ; ^b ; Catherine A. Egan^a
• 刊名：American Journal of Ophthalmology
• 出版年：July 2014
• 年：2014
• 卷：158
• 期：1
• 页码：144-153.e1
• 全文大小：1748 K

文摘

To investigate the association between peripheral and central ischemia in diabetic retinopathy.

Design

Retrospective, cross-sectional.

Methods

Consecutive ultra-widefield fluorescein angiography images were collected from patients with diabetes over a 12-month period. Parameters quantified include the foveal avascular zone (FAZ) area, peripheral ischemic index, peripheral leakage index, and central retinal thickness measurements, as well as visual acuity. The peripheral ischemia or leakage index was calculated as the area of capillary nonperfusion or leakage, expressed as a percentage of the total retinal area.

Results

Forty-seven eyes of 47 patients were included. A moderate correlation was observed between the peripheral ischemia index and FAZ area (r = 0.49, P = .0001). A moderate correlation was also observed between the peripheral leakage index and FAZ area, but only in eyes that were laser naïve (r = 0.44, P = .02). A thinner retina was observed in eyes with macular ischemia (217 ± 81.8 渭m vs 272 ± 36.0 渭m) (P = .02), but not peripheral ischemia (258 ± 76.3 渭m vs 276 ± 68.0 渭m) (P = .24). The relationships between different patterns of peripheral and central macular pathology and visual acuity were evaluated in a step-wise multivariable regression model, and the variables that remained independently associated were age (r = 0.33, P = .03), FAZ area (r = 0.45, P = .02), and central retinal thickness (r = 0.38, P = .01), (R²-adjusted = 0.36).

Conclusions

Ultra-widefield fluorescein angiography provides an insight into the relationships between diabetic vascular complications in the retinal periphery and central macula. Although we observed relationships between ischemia and vascular leakage in the macula and periphery, it was only macular ischemia and retinal thinning that was independently associated with a reduced visual function.