Impulsivity and aggression mediate regional brain responses in Borderline Personality Disorder: An fMRI study

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• 作者：Paul H. Soloff^a ; ^{soloffph@upmc.edu} ; Kristy Abraham^b ; Ashley Burgess^b ; Karthik Ramaseshan^b ; Asadur Chowdury^b ; Vaibhav A. Diwadkar^b
• 关键词：Neuroimaging ; Personality traits ; Affective interference ; Executive cognitive functioning ; Inhibition
• 刊名：Psychiatry Research: Neuroimaging
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：260
• 期：Complete
• 页码：76-85
• 全文大小：666 K
• 卷排序：260

文摘

We assessed effects of impulsivity and aggression on neural processing in subjects with BPD using an Affective Go No-Go task. With negative affect, impulsivity was positively correlated with activation in dACC, OFC, and BG, with no areas of negative correlation. Aggression was negatively correlated with activation in OFC, HIP, and BG with no areas of positive correlation. Negative affect and impulsivity, but not aggression, diminished task performance. Interference with cognitive function results from an interaction between personality traits and affective context.