Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression

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• 作者：Barbara Gellé ; n^a ; ^b ; Katalin Vö ; lgyi^a ; ^b ; Bal&aacute ; zs Andr&aacute ; s Gyö ; rffy^a ; ^c ; Zsuzsa Darula^d ; É ; va Hunyadi-Guly&aacute ; s^d ; Pé ; ter Baracskay^a ; Andr&aacute ; s Czurkó ; ^a ; Istv&aacute ; n Hern&aacute ; di^e ; G&aacute ; bor Juh&aacute ; sz^a ; ^f ; &Aacute ; rp&aacute ; d Dobolyi^b ; Katalin Adrienna Ké ; kesi^a ; ^g ; ^{kakekesi@dec001.geobio.elte.hu} ; ^{kakekesi@ttk.elte.hu}
• 关键词：Clomipramine treatment ; Prefrontal cortex (PFC) ; Two-dimensional differential gel electrophoresis (2D-DIGE) ; Macrophage migration inhibitory factor (MIF) ; Depression-like behavior
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：53-64
• 全文大小：2618 K
• 卷排序：153

文摘

Chronic neonatal clomipramine treatment induces depression-like symptoms in rats. Altered levels of 32 proteins have been revealed in the prefrontal cortex of rats. The macrophage migration inhibitory factor (MIF) showed the largest alteration. MIF is predominantly expressed in astrocytes. Inflammation-associated mechanisms are suggested in this model.