Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
详细信息 查看全文
- 作者：Tobias Eggert1 ; Katharina Wolter2 ; Juling Ji3 ; Chi Ma1 ; Tetyana Yevsa2 ; Sabrina Klotz2 ; José ; Medina-Echeverz1 ; Thomas Longerich4 ; Marshonna Forgues3 ; Florian Reisinger5 ; 6 ; Mathias Heikenwalder5 ; 6 ; Xin Wei Wang3 ; Lars Zender2 ; 7 ; lars.zender@med.uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author ; Tim F. Greten1 ; 8 ; tim.greten@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：senescence ; myeloid cells ; macrophages ; MDSC ; HCC ; liver cancer ; hepatocellular carcinoma ; NK cells ; CCL2 ; CCR2
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：30
- 期：4
- 页码：533-547
- 全文大小：4157 K
文摘
- •
The CCL2-CCR2 axis is necessary for clearance of pre-cancerous senescent hepatocytes
- •
Absence of the CCL2-CCR2 axis leads to HCC outgrowth from senescent hepatocytes
- •
Peritumoral tissue senescence accelerates growth of HCC in mice and humans
- •
Senescence-recruited CCR2+ myeloid cells enhance HCC growth by NK cell inhibition