4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

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• 作者：George P. Lahm ; ^{george.p.lahm@dupont.com} ; Daniel Cordova ; James D. Barry ; Thomas F. Pahutski ; Ben K. Smith ; Jeffrey K. Long ; Eric A. Benner ; Caleb W. Holyoke ; Kathleen Joraski ; Ming Xu ; Mark E. Schroeder ; Ty Wagerle ; Michael J. Mahaffey ; Rejane M. Smith ; My-Hahn Tong
• 关键词：Isoxazolines ; Insecticides
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：15 May, 2013
• 年：2013
• 卷：23
• 期：10
• 页码：3001-3006
• 全文大小：1001 K

文摘

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.