Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease
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- 作者：Caroline Galeotti1 ; 2 ; 3 ; 4 ; Srini V. Kaveri1 ; 2 ; 3 ; 5 ; Rolando Cimaz6 ; Isabelle Koné ; -Paut4 ; Jagadeesh Bayry1 ; 2 ; 3 ; 5 ; jagadeesh.bayry@crc.jussieu.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Drug Discovery Today
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：21
- 期：11
- 页码：1850-1857
- 全文大小：570 K
文摘
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Kawasaki disease (KD) is an acute childhood disease with coronary artery lesions.
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Endothelial cell injury is mediated by T cells and cytokines (TNF-α and IL-1β).
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KD is due to an abnormal immunological response in genetically predisposed individuals.
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Candidate KD susceptibility genes identified by GWAS include BLK, CD40 and FCGR2A.
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Intravenous immunoglobulin and aspirin are the standard treatment of acute KD.
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IVIG-resistant patients are treated with steroids, cyclosporine, anti-IL-1β or anti-TNF.