Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis

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• 作者：Jun Ueda¹ ; ² ; ¹⁰ ; ¹¹ ; ^{junueda@isc.chubu.ac.jp} ; Akihito Harada³ ; ¹⁰ ; Takashi Urahama⁴ ; ¹⁰ ; Shinichi Machida⁴ ; Kazumitsu Maehara³ ; Masashi Hada⁵ ; Yoshinori Makino⁵ ; Jumpei Nogami³ ; Naoki Horikoshi⁴ ; Akihisa Osakabe⁴ ; Hiroyuki Taguchi⁴ ; Hiroki Tanaka⁴ ; Hiroaki Tachiwana⁴ ; Tatsuma Yao⁶ ; ⁹ ; Minami Yamada¹ ; Takashi Iwamoto¹ ; Ayako Isotani² ; Masahito Ikawa² ; Taro Tachibana⁷ ; Yuki Okada⁵ ; Hiroshi Kimura⁸ ; Yasuyuki Ohkawa³ ; Hitoshi Kurumizaka⁴ ; Kazuo Yamagata² ; ⁹ ; ^{yamagata@waka.kindai.ac.jp}
• 关键词：histone variant ; spermatogenesis ; nucleosome ; chromatin ; crystal structure ; epigenetics ; testes ; meiosis ; spermatogonial differentiation ; spermatozoa
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：593-600
• 全文大小：4261 K
• 卷排序：18

文摘

H3t is essential for spermatogenesis, and loss leads to azoospermia H3t is expressed in differentiating spermatogonia but lost from spermatozoa H3t is required for spermatogonial differentiation and ensures entry into meiosis H3t-containing nucleosomes form an open chromatin structure