Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate

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• 作者：Rebeca Kawahara ; Daniela Campos Granato ; Sami Yokoo ; Romê ; nia Ramos Domingues ; Daniel Maragno Trindade ; Adriana Franco Paes Leme ; ^{adriana.paesleme@lnbio.cnpem.br}
• 关键词：Glypican ; Metalloproteinase ; Shedding
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：53-65
• 全文大小：1555 K
• 卷排序：151

文摘

Proteomics approaches revealed novel molecules that are potentially modulated by ADAM17. The shedding of Glypican-1 is metalloproteases-dependent. ADAM17 is direct involved in Glypican-1 shedding. The function of GPC1 may be modulated by proteolysis signaling.