Pathological damage and immunomodulatory effects of zebrafish exposed to microcystin-LR
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- 作者：Chuanyue Chen ; Wanjing Liu ; Li Wang ; Jian Li ; Yuanyuan Chen ; Jienan Jin ; Atufa Kawan ; Xuezhen Zhang ; xuezhen@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microcystin-LR ; Pathological damage ; Immunity ; Recovery ; Fish
- 刊名：Toxicon
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：13-20
- 全文大小：2743 K
文摘
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Subchronic exposure of microcystin-LR causes marked pathological damage in spleen, intestine and gill.
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Fish increase the transcriptional levels of innate immune-related genes to resist the tissue damage.
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Fish exhibit a recovery potential after MC-LR exposure.
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There is a contradiction between the damaged tissues and activated immune genes in fish caused by MC-LR exposure.
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