Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system
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- 作者：Daisuke Aotani ; aotani@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Cheol Son ; Yoshiyuki Shimizu ; Hidenari Nomura ; Takatoshi Hikida ; Toru Kusakabe ; Tomohiro Tanaka ; Takashi Miyazawa ; Kiminori Hosoda ; Kazuwa Nakao ; nakao@kuhp.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; AUC ; area under the curve ; CPP ; conditioned place preference ; DIO ; diet induced obesity ; HFD ; high fat diet ; NCD ; normal chow diet
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：633
- 期：Complete
- 页码：141-145
- 全文大小：539 K
文摘
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Mazindol reduces body weight gain and hyperphagia induced by high-fat diet.
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Mazindol decreases preference for lipid emulsion.
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Mazindol decreases conditioned place preference for high-fat diet.
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Mazindol at the dose required for these effects does not elicit abuse potential.