Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease

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• 作者：Agnete Kirkeby¹ ; ² ; ³ ; ^{agnete.kirkeby@med.lu.se} ; Sara Nolbrant¹ ; ³ ; Katarina Tiklova⁴ ; Andreas Heuer¹ ; ³ ; Nigel Kee⁴ ; Tiago Cardoso¹ ; ³ ; Daniella Rylander Ottosson¹ ; ³ ; Mariah J. Lelos⁵ ; Pedro Rifes² ; ³ ; Stephen B. Dunnett⁵ ; Shane Grealish¹ ; ³ ; Thomas Perlmann⁴ ; Malin Parmar¹ ; ³ ; ⁶ ; ^{malin.parmar@med.lu.se}
• 关键词：Parkinson&rsquo ; s disease ; human embryonic stem cells ; hESCs ; dopaminergic neurons ; diencephalon ; transplantation ; subthalamic nucleus ; STN ; ventral midbrain ; VM ; midbrain-hindbrain boundary ; MHB ; FGF8 ; good manufacturing practice ; GMP
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：135-148
• 全文大小：8346 K
• 卷排序：20

文摘

Common markers of hESC-derived DA progenitors correlate poorly with graft outcome RNA-seq reveals correlation of caudal midbrain markers with DA neuron yield in vivo Staged application of FGF8b patterns hESC-derived progenitors to a caudal VM fate GMP adaptation of differentiation using this approach improves transplant outcome