Pulmonary hypertension associated with diffuse deposition of pentosidine in pulmonary arterioles

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• 作者：Komoda Munenori^a ; Riko Kitazawa^a ; Kenji Makita^a ; Keisuke Yoshida^a ; Miyuki Takeji^b ; Yoshiko Soga^b ; Mie Kurata^c ; Ryuma Haraguchi^a ; Sohei Kitazawa^a ; ^{kitazawa@m.ehime-u.ac.jp}
• 关键词：Pulmonary hyprtension ; Diabetes ; Pentosidine ; Autopsy
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：100
• 期：2
• 页码：e59-e62
• 全文大小：2720 K

文摘

Diabetes induces advanced glycation end products (AGEs) that per se are not only a major cause of oxidative stress but also reduce the plasticity of connective tissue by pathological collagen cross-linking. We describe a case of severe pulmonary hypertension manifesting as a major diabetic complication. Impaired pulmonary arteriolar plasticity attributed to pentosidine, together with increased circulation volume by hyperosmotic pressure and reduction in myocardial compliance by multiple patchy fibrosis, may contribute to the clinical manifestation of severe pulmonary hypertension.