The role of the AMPA receptor and 5-HT3 receptor on aggressive behavior and depressive-like symptoms in chronic social isolation-reared mice
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- 作者：Koh Shimizu ; Natsuki Kurosawa ; Kenjiro Seki ; k-seki@pha.ohu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; NMDA ; N-methyl-D-aspartate receptor ; SDS ; sodium dodecyl sulfate ; PVDF ; polyvinylidene difluoride ; BSA ; bovine serum albumin ; ECL ; enhanced chemiluminescence ; GABA ; gamma-aminobutyric acid ; BNST ; bed nucleus of the stria terminalis ; DMN ; dorsal medial nucleus ; PVN ; hypothalamic paraventricular nucleus ; HPA ; hypothalamic-pituitary-adrenocortical ; 5-HT ; serotonin ; SI ; social isolation ; NBQX ; 2 ; 3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quino
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：153
- 期：Complete
- 页码：70-83
- 全文大小：1584 K
文摘
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The hypothalamic 5-HT3 receptor was down–regulated by chronic social isolation (SI).
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The amygdalar AMPA receptor subunits were up-regulated by chronic SI.
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Intra-amygdalar infusion of (S)-AMPA exhibited the despair-like behavior.
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A systemic 5-HT3 receptor agonist abolished the aggression in chronic SI mice.
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A systemic 5-HT3 receptor agonist enhanced the aggression in short-term SI mice.