Data set of Aspergillus flavus induced alterations in tear proteome: Understanding the pathogen-induced host response to fungal infection

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• 作者：Jeyalakshmi Kandhavelu^a ; ¹ ; Naveen Luke Demonte^a ; ¹ ; Venkatesh Prajna Namperumalsamy^b ; Lalitha Prajna^c ; Chitra Thangavel^a ; Jeya Maheshwari Jayapal^a ; Dharmalingam Kuppamuthu^a ; ^{dharmalingam.k@gmail.com}
• 关键词：Mycotic keratitis ; Tear ; Inflammation ; Proteomics ; Glycosylation ; Complement ; NETosis ; Wound healing
• 刊名：Data in Brief
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：Complete
• 页码：888-894
• 全文大小：931 K
• 卷排序：9

文摘

Fungal keratitis is one of the leading causes of blindness in the tropical countries affecting individuals in their most productive age. The host immune response during this infection is poorly understood. We carried out comparative tear proteome analysis of Aspergillus flavus keratitis patients and uninfected controls. Proteome was separated into glycosylated and non-glycosylated fractions using lectin column chromatography before mass spectrometry. The data revealed the major processes activated in the human host in response to fungal infection and reflected in the tear. Extended analysis of this dataset presented here complements the research article entitled “Aspergillus flavus induced alterations in tear protein profile reveal pathogen-induced host response to fungal infection [1]” (Jeyalakhsmi Kandhavelu, Naveen Luke Demonte, Venkatesh Prajna Namperumalsamy, Lalitha Prajna, Chitra Thangavel, Jeya Maheshwari Jayapal, Dharmalingam Kuppamuthu, 2016). The mass spectrometry proteomics data have been deposited in the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE:PXD003825.