Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects

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• 作者：Megan R. Ruth ; Ava M. Port ; Mitali Shah ; Ashley C. Bourl ; Nawfal W. Istfan ; Kerrie P. Nelson ; Noyan Gokce ; Caroline M. Apovian
• 关键词：HFLC ; high fat low carbohydrate ; LFHC ; low fat high carbohydrate ; hs-CRP ; high sensitivity-C-reactive protein ; HDL ; high density lipoprotein ; LDL ; low density lipoprotein ; HMW ; high molecular weight ; TNF-伪 ; tumor necrosis factor-alpha ; BMI ; body mass index ; HbA1C ; hemoglobin A1C ; DXA ; dual energy x-ray absorptiometry ; FMD ; flow mediated dilation ; ELISA ; enzyme-linked immunosorbent assay ; OGTT ; oral glucose tolerance test ; HOMA-IR ; homeostatic model assessment-insulin resistance ; AUC ; area under
• 刊名：Metabolism
• 出版年：December, 2013
• 年：2013
• 卷：62
• 期：12
• 页码：1779-1787
• 全文大小：399 K

文摘

Objective

High fat, low carbohydrate (HFLC) diets have become popular tools for weight management. We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate (LFHC) diet on the change in weight loss, cardiovascular risk factors and inflammation in subjects with obesity.

Methods

<p>Obese subjects (29.0-44.6 kg/mp>2p>) recruited from Boston Medical Center were randomized to a hypocaloric LFHC (n = 26) or HFLC (n = 29) diet for 12 weeks.

Results

<p>The age range of subjects was 21-62 years. As a percentage of daily calories, the HFLC group consumed 33.5% protein, 56.0% fat and 9.6% carbohydrate and the LFHC group consumed 22.0% protein, 25.0% fat and 55.7% carbohydrate. The change in percent body weight, lean and fat mass, blood pressure, flow mediated dilation, hip:waist ratio, hemoglobin A1C, fasting insulin and glucose, and glucose and insulin response to a 2 h oral glucose tolerance test did not differ (P > 0.05) between diets after 12 weeks. The HFLC group had greater mean decreases in serum triglyceride (P = 0.07), and hs-CRP (P = 0.03), and greater mean increases in HDL cholesterol (P = 0.004), and total adiponectin (P = 0.045) relative to the LFHC. Secreted adipose tissue adiponectin or TNF-伪 did not differ after weight loss for either diet.

Conclusions

<p>Relative to the LFHC group, the HFLC group had greater improvements in blood lipids and systemic inflammation with similar changes in body weight and composition. This small-scale study suggests that HFLC diets may be more beneficial to cardiovascular health and inflammation in free-living obese adults compared to LFHC diets.