Dose-response characteristics of intravenous ketamine on dissociative stereotypy, locomotion, sensorimotor gating, and nociception in male Sprague-Dawley rats

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• 作者：Kennett D. Radford^a ; Thomas Y. Park^b ; ^c ; Bong Hyo Lee^b ; ^d ; Sean Moran^e ; Lisa A. Osborne^a ; Kwang H. Choi^a ; ^b ; ^c ; ^{kwang.choi@usuhs.edu}
• 关键词：Ketamine ; Rat ; Intravenous ; Locomotor activity ; Dissociative stereotypy ; Sensorimotor gating ; Antinociception
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：130-140
• 全文大小：1116 K
• 卷排序：153

文摘

Intravenous (IV) ketamine is a valid administration route for rat behavior studies. Ketamine IV bolus induced hyper-locomotion, impaired PPI, and antinociception. Ketamine IV infusion induced hypo & hyper-locomotion and extended antinociception. A high-dose ketamine infusion reduced acoustic startle and impaired PPI. Plasma ketamine concentrations rapidly declined after bolus and infusion administration.