Effects of Shenfu injection on macrocirculation and microcirculation during cardiopulmonary resuscitation

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• 作者：Junyuan Wu¹ ; ^{wu007838@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Chunsheng Li ; ² ; ^{lcscyyy001@sohu.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Yuan³ ; ^{2000ywei@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ketamine (PubChem CID ; 3821) ; Propofol (PubChem CID ; 4943) ; Pentobarbital (PubChem CID ; 4734) ; Ginsenoside (PubChem CID ; 9918693) ; Aconitine (PubChem CID ; 245005) ; Ginseng (PubChem CID ; 9898279) ; Radix aconiti lateralis preparata (PubChem CID ; 21115231) ; Aconitum carmichaeli Debx (PubChem CID ; 157615) ; Ranunculaceae (PubChem CID ; 353743)
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：2 March 2016
• 年：2016
• 卷：180
• 期：Complete
• 页码：97-103
• 全文大小：997 K

文摘

To examine the effects of Shenfu injection (SFI) on macrocirculation and microcirculation during ventricular fibrillation (VF) and cardiopulmonary resuscitation (CPR).

Materials and methods

Sixteen female Landrace pigs were used in this study. After anesthesia, coronary perfusion pressure (CPP) was measured, and then the abdominal cavity was opened to observe the mesenteric microcirculation with the aid of sidestream dark field imaging. Following the guidelines, we determined microvascular flow index, perfused vessel density and proportion of perfused vessels both for large (diameter>20 μm) and small (diameter<20 μm) microvessels. SFI (1 ml/kg) or saline was given by vein injection at 1 h before inducing VF. CPR was initiated after 4 min VF.

Results

The shocks and duration of CPR were less in the SFI group compared with saline group. As the occurrence of VF, the CPP suddenly dropped to near zero, and cannot be measured in the both groups. However, there was greater CPP during CPR and at 1 h after return of spontaneous circulation in the SFI group than saline group. Compared with saline, SFI significantly improved the microcirculation parameters of large and small microvessels during VF and CPR.

Conclusions

SFI can improve the microvascular blood flow and CPP during VF and CPR, and reduce the shocks and duration of CPR.